新闻 · arXiv cs.LG

COAST: Context-Aware Differential Learning for Gene Expression Prediction in Spatial Transcriptomics

Spatial transcriptomics enables profiling of spatial gene expression but is limited by high cost and low throughput, motivating prediction from H&E histopathology images. Existing context-aware methods mainly supervise absolute expression, while relative expression relationships between spots are rarely used explicitly. We propose COAST, a context-aware differential learning framework for spatial gene expression prediction. COAST conditions the local and global context features with…